Chiral Resource Center

 

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Welcome to the Chiral Resource Center sponsored by PDR-Chiral Inc.


Introduction

PDR-Chiral Inc., makers of the Advanced Laser Polarimeter, has created this web site in order to provide analytical chemists with a basic understanding of detection used in chiral analysis. It is our hope that a better understanding of chiral detection will lead to additional research in the field of optically active compounds and the roles they play in everyday life.

The interest in compounds possessing optical activity has increased quite dramatically over the past 10 years. The major reason has been the realization that many compounds exhibiting biological activity also exhibit optical activity. By their very nature, these optically active compounds occur in two or more, chemically identical but structurally different forms.

Typically, only one of the forms exhibits pharmacological potency while other forms may be biologically inactive or, in the worst case, toxic. Consequently, pharmaceutical companies now have significant interest in monitoring optical activity not only as a QA/QC function but also in an effort to optimize production conditions.

The Chiral Resource Center is divided into 9 sections as listed below. It has been organized to allow the reader to move freely between sections. The Chiral Resource Center can also be downloaded in its complete form as a handy reference.

Chiral Detection

Chiral detection and how it is used by the analytical chemist

Examples

Examples of typical chiral analyses

Publications

Online papers utilizing the Advanced Laser Polarimeter in chiral applications

Laser Polarimeter

An introduction to the PDR-Chiral Advanced Laser Polarimeter

Theory of Operation

The PDR-Chiral Advanced Laser Polarimeter theory of operation

Specific Rotation

Calculating specific rotation and enantiomeric ratio

Chemical Effects

Effects of concentration, solvent and pH on optical rotation

Limits of Detection

Calculating practical limits of detection for enantiomers

OR versus CD

A comparison between laser polarimetry and circular dichroism

Equations

Theoretical equations used in optical activity calculations

Download Area

Downloadable tools

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