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Laser Polarimeter |
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Description The PDR chiral detector is a sensitive, stable, easy-to-use Advanced Laser Polarimeter useful for quantitating enantiomers and enantiomeric ratios. Overall performance is significantly better than any other polarimeter currently available. Often placed after the UV detector in an HPLC system, it is used to measure the magnitude and direction of optical rotation of a sample as it passes through the flow cell. The measurement of rotation is direct and the output goes positive or negative depending on the samples’ optical activity. The use of a custom-designed, 670nm diode laser source eliminates anomalies normally seen with chiral detectors based on continuous spectrum light sources. The ALP can be used in production environments to monitor net optical activity of the contents of reaction vessels. It is also used in high-throughput screening to identify chiral centers and enantiomers. Additionally it can be used to detect optically active fractions from preparative HPLC systems, simulated moving bed (SMB) systems, and many other applications. The ALP's 2-level, bi-modal internal calibration feature can be used to determine specific rotation and enantiomeric ratios, self-validate chromatograms, etc. Data System Requirements The PDR Chiral Detector is compatible with all HPLC systems. The detector requires a 0-1 volt analog input channel and 3 contact closures (autozero + 2 calibration levels) for fully automatic operation. Custom options are available. Bench Space Requirements The detector is designed to fit under most HPLC stacks (e.g. HP1100). The convenient rear panel interface connector can be removed / rewired / installed without moving the instrument.
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